This residence, built by Mrs Prada as a gift for her husband Dr Enrique Prada, was the home of the Prada family for 19 years. The name Mille Fleurs is original and was bestowed upon the structure by Mrs Prada herself. The house was built in 1904 by George Brown of the Trinidad Trading Company, under the guidance of Dr Prada, who had a particular interest in building. Dr Prada was a scholar and a public-minded man. Born in Venezuela in 1867, he came to Trinidad at an early age where he lived until his death in 1944.

In 1923, Mille Fleurs was sold to Joseph Salvatori, from which time it became the residence of the Salvatori family. After the death of Mr Salvatori in 1959. Mrs Salvatori was the sole occupant until her death in 1971. The mansion subsequently became the property of Mrs Pierre Lelong, only daughter of Mr and Mrs Salvatori. Mrs Lelong lived in Paris and in 1973 she sold the Mille Fleurs to George Matouk. In June 1979, the government of Trinidad and Tobago purchased the house from Mr Matouk.

Since then the building has been used by industrial cottages and community business program and as the headquarters for Carifesta V in 1991. The building stayed under the jurisdiction of the Ministry of Culture for a number of years. In June 2000, it was assigned to the Ministry of Environment.

Its architectural style has been described as French Provincial. Although Mille Fleurs is less ostentatious as some of its neighbours, the quality of finish and detailing is perhaps of a far higher quality; the intricately carved balusters and the marble treads and risers to both the main and secondary staircases, the elaborate cast iron columns and brackets.

The restoration of Mille Fleurs was completed in 2020, and was handed over to the National Trust of Trinidad and Tobago.